KAIMRC Research Highlight

Cause found for rare amino acid disease

A young Saudi girl’s metabolic disorder can be explained by a newly discovered gene mutation.

Majid Alfadhel / Human Genetics

Research highlights

KAIMRC Innovations highlights the most exciting research taking place at the different research centers in KAIMRC. The research highlights are informative articles that cover breakthrough research and are accessible to the wider science community and a general audience interested in science. With regular weekly updates, this is the place to keep up with the best clinical and medical research happening at KAIMRC and around the world.

KAIMRC Research Highlight
The Saudi approach to curing childhood leukaemia

April 25, 2017

The survival rate for paediatric acute myeloid leukaemia in Saudi Arabia is nowequal to that of developed nations thanks to a risk–response strategy.

KAIMRC Research Highlight
Potential for a MERS antibody therapy

April 11, 2017

Patients with Middle East Respiratory Syndrome may produce sufficient antibodies to help fight the viral infection in more recentvictims.

International Research Highlight
Beta cell boost could replace insulin injections

February 28, 2017

A strategy for deriving beta cells from patients with type I diabetes could transform disease treatment.

KAIMRC Research Highlight
Mixed messages on wider effects of vaccines

February 26, 2017

Vaccines against tuberculosis, diphtheria, tetanus, pertussis and measles may have effects on other aspects of health.

International Research Highlight
Concerns raised about digoxin safety

January 15, 2017

A drug commonly used to treat heart failure could be associated with an increased risk of death in certain patient groups.

KAIMRC Research Highlight
Strategy urged to tackle genetic disease

January 14, 2017

A high rate of inherited metabolic disorders in Saudi Arabia is prompting calls for action.

KAIMRC Research Highlight
Smart nanoparticles for cancer drug delivery

January 10, 2017

Magneto-fluorescent nanoparticles successfully deliver anti-cancer drug to breast cancer cells.

International Research Highlight
Radiolabeled peptides could monitor diabetes progression

January 9, 2017

Radioactive peptides effectively image insulin-producing cells, with potential to chart disease progression in diabetes.

International Research Highlight
Powerful tool invented to probe entire human proteome

January 4, 2017

The technology could give the search for new drugs, especially for cancer and terminal diseases, a significant boost.

International Research Highlight
Targeting cancer through the skin

January 1, 2017

More medicines could soon be delivered through the skin by cargo-carrying peptides.

KAIMRC Research Highlight
Balancing CT dose and image quality

December 25, 2016

New techniques to improve image quality in CT scans while reducing radiation dose may compromise quality at certain thresholds, potentially resulting in misdiagnosis.

International Research Highlight
Chinese herbal remedies yield anti-cancer drug leads

December 20, 2016

A shortlist of Chinese medicinal plants containing the most anti-cancer compounds could yield new drugs for patients.

KAIMRC Research Highlight
Preventing flu in kidney transplant patients

December 16, 2016

A flu shot may also benefit transplant patients under age 65.

International Research Highlight
Hepatitis B: Predict, treat, avoid

December 16, 2016

A biomarker has been found that can help predict the reactivation of the hepatitis B virus in immunosuppressed patients.

KAIMRC Research Highlight
Gene ties autism and kidney issues

December 15, 2016

Mutations in the “teashirt” gene cause both an autism syndrome and kidney problems in children.

KAIMRC Research Highlight
Light-responsive shape-changing molecules

December 13, 2016

Nanowires that undergo reversible shape-changes in response to light could act as artificial tails to steer drugs around the body.

KAIMRC Research Highlight
A new player in gene regulation

December 10, 2016

The molecular mechanism controlling gene expression is found to involve a familiar molecule.

International Research Highlight
Go Mediterranean for cancer protection

December 10, 2016

A Mediterranean diet reduces the risk of colorectal cancer by half in Italy.

KAIMRC Research Highlight
Shedding new light on cancer cell death

December 9, 2016

Insight into the antibody-driven death of lymphoma cells may lead to anti-cancer treatments with enhanced efficacy and selectivity.

International Research Highlight
Shedding light on tumours

December 6, 2016

A contrast agent, containing nanoparticles that are sensitive to acidity, lights up solid tumours on magnetic resonance imaging scans.

International Research Highlight
Scrutinizing cellular bonds in heart failure patients

December 6, 2016

Atomic force microscopy can help scientists identify which chronic heart failure patients are more likely to suffer complications.

International Research Highlight
Honing in on thyroid cancer

December 3, 2016

A closer look at gene expression in papillary thyroid cancer opens new opportunities for its detection.

International Research Highlight
‘Young blood’ a defence against infection

December 2, 2016

Signatures of a more potent and durable immune response may explain why children fend off chronic hepatitis C infection better than adults.

International Research Highlight
Reaching for success is easier for the tall

November 30, 2016

A broad survey of British men and women suggests hereditary differences in height and weight affect prospects for socioeconomic positioning.

International Research Highlight
The genetics of smoking behaviour and lung disease

November 29, 2016

Samples reveal specific genetic signals that determine a person’s risk for tobacco addiction and lung damage from smoking.

KAIMRC Research Highlight
Exploring diabetes impact on teenagers and their families

November 22, 2016

A multidisciplinary approach to treating teenage diabetics is needed to improve quality of life for patients and their families.

International Research Highlight
Obesity surgery can also resolve diabetes

November 22, 2016

Large-scale study shows bariatric surgery helps keep weight down and can resolve diabetes and hypertension.

KAIMRC Research Highlight
An attractive and abundant stem cell alternative

November 20, 2016

Stem cells derived from the maternal side of the human placenta may find unique therapeutic applications given their special properties.

KAIMRC Research Highlight
Gene defects reduce leukaemia survival

November 14, 2016

Genetic variations can explain poorer survival rates in Pakistani children from a prevalent type of leukaemia.

International Research Highlight
How hepatitis C takes control

November 2, 2016

The hepatitis virus commandeers key cellular machinery to keep itself safe.

International Research Highlight
Making room for regeneration

November 1, 2016

Drugs that prevent the accumulation of scar-forming molecules could facilitate nerve repair in multiple sclerosis and other disorders.

KAIMRC Research Highlight
Safeguarding diabetes patients in Ramadan

August 20, 2016

Millions of Muslims with diabetes are at risk if they fast during Ramadan without guidance.

KAIMRC Research Highlight
Peptide promise for diagnostics

August 17, 2016

Rapid diagnosis of HIV may soon be possible thanks to a novel peptide-based diagnostic tool.

KAIMRC Research Highlight
Autistic children could receive tailored treatment

August 14, 2016

A new method of identifying autism means the hope of earlier treatment for children.

KAIMRC Research Highlight
Donating blood might improve diabetes

August 14, 2016

Recent research suggests giving blood may temporarily improve insulin production and glucose tolerance.

KAIMRC Research Highlight
Recipes for better drug delivery

August 14, 2016

Fine-tuned nanocarriers loaded with natural products may improve targeted drug delivery and enhance anti-cancer activity

KAIMRC Research Highlight
A biomarker for colorectal cancer

August 14, 2016

A mutated tumour suppressor gene could provide a useful marker for the diagnosis and prognosis of bowel cancer.

KAIMRC Research Highlight
New anticancer molecule promises improved therapy

August 14, 2016

Chemotherapy without side effects, or the risk of relapse, could soon be possible.

International Research Highlight
The hunt for dementia’s molecular triggers

August 14, 2016

Gender differences provide molecular clues for scientists seeking better ways to treat dementia.

International Research Highlight
New probe shines light inside arteries

August 14, 2016

A new design of catheter probe reveals complete, detailed pictures of fat deposits inside arteries for the first time.

International Research Highlight
First MERS autopsy yields ‘critical insights’

August 14, 2016

The world’s first autopsy of a patient with Middle East respiratory syndrome shows that the lungs are the infection’s main target.

KAIMRC Research Highlight
Fanconi anaemia may be under-diagnosed in Saudi Arabia

August 14, 2016

Genetic analysis of Saudi patients with Fanconi anaemia reveals new mutations and distinct patterns of mutation that may affect diagnosis.

KAIMRC Research Highlight
Strictly confidential

August 14, 2016

Protecting confidentiality is a major priority in medical settings, crucial to the effectiveness of Saudi Arabia's newly established biobank.

KAIMRC Research Highlight
Genetic variants alter breast cancer risk

August 14, 2016

Genetic variants of the DNA repair protein RAD51 are associated with differential risks of breast cancer in Saudi women.

International Research Highlight
Unmaking a muscle

August 14, 2016

The ‘missing links’ in a process that drives muscle wasting in heart failure patients may offer promising drug targets.

International Research Highlight
A protective coat for nanoparticles

August 14, 2016

Nanoparticles coated in a ‘don’t-eat-me’ protein can evade the body’s immune system, improving chances of successful drug delivery.

KAIMRC Research Highlight
Understanding risks of consanguineous reproduction

August 14, 2016

Saudi Arabia needs a widespread education program highlighting the genetic risks to children born as a result of marriage within families.

KAIMRC Research Highlight
Oral cancer in the Arab World

August 14, 2016

Qat and tobacco chewing have been linked to a higher incidence of oral cancer in Yemen, Sudan and southern Saudi Arabia than in other Arab countries.

International Research Highlight
The metabolomics revolution

August 14, 2016

Understanding the body’s metabolic profile is transforming drug discovery and personalized medicine.

International Research Highlight
Hepatitis B poses lifetime cancer risk

August 14, 2016

Clearance of active hepatitis B virus from the blood does not reduce the risk of liver cancer.

KAIMRC Research Highlight
Gene tweak induces stronger immunity

August 14, 2016

Changing the switch that turns on vaccine protein production elicits a stronger immune response against malaria and influenza in mice.

KAIMRC Research Highlight
New chemotherapy promising for breast cancer

August 14, 2016

A trial for a new chemotherapy treatment has shown promising results for locally advanced breast cancer.

KAIMRC Research Highlight
A safer route to a cure

August 14, 2016

Clinical data suggests many adolescent Hodgkin lymphoma patients can achieve full recovery with a less toxic course of therapy.

International Research Highlight
Silkworms’ sweet success

August 14, 2016

Silkworms could point toward a new preventative therapy for type II diabetes.

International Research Highlight
Promising protein target

August 11, 2016

A structural analysis of proteins in the Middle East Respiratory Syndrome virus reveals a promising new target for treatments.

International Research Highlight
Drug-carrying nanoparticles not reaching targets

August 11, 2016

 The targeted delivery of drug-carrying nanoparticles to solid tumours needs improvement before it can be effective in humans.

International Research Highlight
Drug study shines new light on receptors

August 11, 2016

Identifying the binding site of an antagonist is expected to transform the treatment of diabetes and other metabolic diseases. 

International Research Highlight
Latest technique delivers CRISPR gene screens

August 11, 2016

A comparison of gene editing techniques reveals benefits of latest technology over conventional approach.

International Research Highlight
Making room for regeneration

August 11, 2016

Drugs that prevent the accumulation of scar-forming molecules could facilitate nerve repair in multiple sclerosis and other disorders.

International Research Highlight
How hepatitis C takes control

August 11, 2016

The hepatitis virus commandeers key cellular machinery to keep itself safe.

International Research Highlight
The truth about fatty acids

August 11, 2016

A Dutch cohort study shows that saturated fatty acids might not be as bad as people think.

International Research Highlight
Tracking the effects of therapeutic genes

August 11, 2016

Targeted nanoparticles offer hope of better methods for tracking the effects of gene therapy.

KAIMRC Research Highlight
Manipulating metals for medicine

August 11, 2016

A simple and robust synthetic method could help magnetic metal oxide nanoparticles reach their potential as a powerful clinical tool.

International Research Highlight
Reversing immune decline

August 10, 2016

Targeting a certain gene could help promote healthy aging.

KAIMRC Research Highlight
How long do we treat the critically ill?

August 10, 2016

Researchers are developing objective measures to determine whether critically ill cancer patients can benefit from intensive care.

KAIMRC Research Highlight
Molecular tool detects early-stage breast cancer

August 10, 2016

A cheap, simple test shows potential for reducing uncertainty in the diagnosis of early-stage breast cancer.

KAIMRC Research Highlight
Early fitness improves heart attack survival

August 10, 2016

Keeping fit early on can increase chances of survival from a heart attack later in life

KAIMRC Research Highlight
More may not be better for the critically ill

August 10, 2016

Critically ill adults may do as well or better on fewer calories.

KAIMRC Research Highlight
Eliminating risk factors of heart attack

July 8, 2016

Sex has no effect on increasing the risk of a major heart attack for patients with extensive coronary artery disease.

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