New type 1 diabetes treatment targets

New avenues are opening for better control of type 1 diabetes, with some now showing promise in clinical trials


Therapeutics Research highlights

KAIMRC Innovations highlights the most exciting research taking place at the different research centers in KAIMRC. The research highlights are informative articles that cover breakthrough research and are accessible to the wider science community and a general audience interested in science. With regular weekly updates, this is the place to keep up with the best clinical and medical research happening at KAIMRC and around the world.

KAIMRC Research Highlight
Promising nanoparticle carrier for chemo drug

January 10, 2022

Using nanoparticles to deliver the existing chemotherapy drug epirubicin could improve its efficacy and safety

KAIMRC Research Highlight
Anticoagulant satisfaction survey translated into Arabic

January 3, 2022

The quality of life of Arabic patients on long-term anticoagulant drugs can be comprehensively assessed by a translated version of an international satisfaction scale

KAIMRC Research Highlight
Trial begins on antiviral drug for COVID-19

November 15, 2021

A clinical trial in Saudi Arabia will examine the efficacy of an existing antiviral in treating mild COVID-19

KAIMRC Research Highlight
Optimizing treatment regimens for childhood acute lymphoblastic leukaemia

November 1, 2021

A multinational study shows that radiotherapy with chemotherapy before hematopoietic stem cell transplantation improves the survival of children with acute lymphoblastic leukaemia compared with multi-agent chemotherapy.

International Research Highlight
Existing drugs may help with COVID-19 treatment

October 18, 2021

Computational screening of SARS-CoV-2 genomes identified several proteins which could be targeted by existing drugs to treat COVID-19

KAIMRC Research Highlight
New model predicts the risk of blood thinners for Arabs

October 11, 2021

A novel model that predicts bleeding risk in Arab patients taking direct oral anticoagulants shows good sensitivity and specificity.

International Research Highlight
Combined therapy boosts kidney cancer survival rates

October 7, 2021

A global phase 3 clinical trial demonstrates the efficacy of a novel combined therapy for advanced kidney cancer

International Research Highlight
A dynamic duo to fight MERS

September 30, 2021

Experiments in mice suggest that a two-antibody cocktail could prevent infection with the Middle East respiratory syndrome coronavirus.

KAIMRC Research Highlight
Immune checkpoint inhibitors cause mild to severe side effects

September 23, 2021

A small Saudi study shows that the cancer therapy commonly causes mild side effects but sometimes more severe side effects

KAIMRC Research Highlight
Animating the inanimate

August 19, 2021

Swimming crystalline microwires could be the progenitors of futuristic microrobotics systems.

KAIMRC Research Highlight
A properly packaged mix overcomes antibiotic-resistant bacteria

August 12, 2021

Liposomes carrying the right drug combination could help in the fight against drug-resistant microbes

International Research Highlight
Nanotechnology prevents preterm birth in mice

August 5, 2021

Formulation helps overcome mucus barriers for targeted drug delivery

Reducing chronic maladaptive inflammation rejuvenates brain cells in mice

August 2, 2021

Scientists pinpoint a single molecular signalling pathway that could be used to reverse age-associated metabolic and immune dysfunction in mice.

KAIMRC Research Highlight
Seatbelt use in Saudi Arabia remains low

July 15, 2021

A survey reveals that young adults, women and people suffering from depression and anxiety are less likely to buckle up

International Research Highlight
A fatty diet disturbs circadian brain metabolism

June 24, 2021

A high-fat diet changes metabolic oscillations in brain regions that control circadian rhythms.

KAIMRC Research Highlight
Investigating the factors affecting burn patient survival

June 17, 2021

Data from patients on mechanical ventilation offers insight into factors affecting survival

KAIMRC Research Highlight
Family support hastens recovery

April 14, 2021

Family ties are key for successful recovery from injuries that can lead to temporary or permanent disability.

KAIMRC Research Highlight
Prevalence of blood clotting after hip procedures

March 10, 2021

Venous thromboembolism after hip procedures is not abnormally  common in Saudi Arabia

KAIMRC Research Highlight
Measures needed to reduce road casualties

March 3, 2021

Study highlights global disparities in improving traffic safety

Reducing MERS mortality

February 22, 2021

Clinicians have tested a combination drug regimen that reduces the number of deaths from Middle East Respiratory Syndrome by a third.

KAIMRC Research Highlight
IVF conception does not affect educational outcomes of premature children

February 10, 2021


International Research Highlight
Measuring the risk of contracting latent tuberculosis in clinical training

December 23, 2020

Medical students face a greater risk of being infected with TB bacteria than trainees in other specializations

International Research Highlight
Gut microbe transplant treats graft versus host disease

December 2, 2020

Faecal bacteria from healthy donors can save the lives of blood stem cell transplant recipients

International Research Highlight
Hair-growing skin produced from human stem cells

November 18, 2020

Complete skin-in-a-dish tissue offers new options for wound healing, genetic skin conditions and baldness. 

Clinical Trials: A hopeful start in Saudi Arabia

August 19, 2020

Early signs suggest that Saudi Arabians are willing to embrace and participate in the kingdom’s new human clinical trials programme.

KAIMRC Research Highlight
Nix the mix

August 4, 2020

Vitamin D testing does not require the mixing of samples, a finding that could save lab technicians time and effort.

KAIMRC Research Highlight
Speedy test for antibiotic resistance

July 14, 2020

A test for antibiotic-resistant bacteria shows scope for further development

International Research Highlight
Supercharged immune cells to fight lymphoma

July 7, 2020

An immunotherapy approach, based on adapting a patient’s immune cells to tackle specific cancer cells, shows promise against rare lymphoma.

Scope for greater use of digital tools in Saudi healthcare

June 1, 2020

A study on the use of smartphones in the Saudi healthcare system shows that while penetration rates are high, medical workers in the kingdom are reluctant to use mobiles for work purposes.  

KAIMRC Research Highlight
The molecular mechanism linking melatonin and memory

May 31, 2020

Revealing how melatonin alleviates memory defects opens new therapeutic avenues

KAIMRC Research Highlight
The battle of the diagnostics

May 24, 2020

New study compares CT scans with MRIs for cervical spine injury detection in unconscious paediatric patients

KAIMRC Research Highlight
Diagnostics: Nix the mix

May 4, 2020

Vitamin D testing does not require the mixing of samples, a finding that could save lab technicians time and effort.

International Research Highlight
Stem cell therapy: Insights into heart repair mechanisms

April 21, 2020

The injection of stem cells into the heart following cardiac arrest induces an innate immune response that helps repair damaged tissues.  

International Research Highlight
Artificial intelligence enhances in-surgery tumour analysis

April 5, 2020

An automated system can provide diagnostic information during surgery for a brain tumour with a similar accuracy to pathologists.

International Research Highlight
A mother’s protective gift to pre-term babies

March 10, 2020

Preterm babies have a similar arsenal of maternal antibodies to those of full-term babies, suggesting that their higher infection risk is due to other factors. 

KAIMRC Research Highlight
Laying bare the skeleton foundations

February 16, 2020

New research concludes that the proper organization of the cell skeleton during bone cell formation is regulated by TGFβ1, a key growth factor

Seeking cures for Alzheimer’s disease

February 9, 2020

Advances in Alzheimer’s research over the past few years are increasing hopes of finding more effective treatments, while implicating bacteria as a possible cause

International Research Highlight
Birth weight estimates updated

January 23, 2020

New research provides more accurate charts for assessing birth weight based on updated information to identify need for infant care

International Research Highlight
A rocking good sleep

January 12, 2020

Study reveals that the gentle rocking motion that soothes children to sleep works just as well for adults, and also keeps their memory strong.  

International Research Highlight
Wearing diabetes care lightly

December 30, 2019

A new wearable, flexible nanosensor could help monitor glucose levels without the need for blood tests 

A smart way to beat the heat

December 22, 2019

KAIMRC researchers develop a system that can regulate body temperature in real time to help treat heatstroke patients.

KAIMRC Research Highlight
Curbing excessive antimicrobial use 

November 20, 2019

High levels of antibiotic use in intensive care units across Saudi Arabia are exacerbating the antibiotic resistance problem.

International Research Highlight
Heartening findings on an aortic surgery alternative

November 10, 2019

A minimally invasive alternative to heart surgery may offer better outcomes for treating a broader range of patients with aortic stenosis 

International Research Highlight
Brains of blind people adapt to sharpen sense of hearing

November 6, 2019

People with impaired vision have sharpened and nuanced sense of hearing.

KAIMRC Research Highlight
Bacteria in sperm hinders fertility treatment

September 29, 2019

The presence of bacteria in semen reduces sperm quality with a knock-on effect on the success of IVF treatments

KAIMRC Research Highlight
Hungry for heart health

September 15, 2019

Study in rats shows that hunger hormone helps preserve cardiac muscle cells and reduce heart attack damage

Train efficiently, not more

September 2, 2019

New research by the University of Glasgow suggests that 15 minutes of resistance training to the point of exhaustion three times a week can have the same health benefit as longer sets.

Putting Saudi Arabia on the clinical trial map

August 26, 2019

KAIMRC’s new initiative stands to kickstart Saudi Arabia’s clinical trials economy, and find treatments for its people.

A year of biomedicine breakthroughs

July 28, 2019

The latest global innovations in the study of disease

International Research Highlight
Trimming the stomach lining to fight fat

June 26, 2019

Research suggests that targeting the stomach lining may alleviate obesity.

KAIMRC Research Highlight
Cardiovascular health: The power of machine learning 

May 5, 2019

Machine learning accurately predicts the association between cardio-respiratory fitness and mortality.

KAIMRC Research Highlight
A vital test for spinal muscular atrophy

April 7, 2019

A new chip-based sensor could detect and monitor spinal muscular atrophy faster and more cheaply than current methods.

International Research Highlight
Breakthrough in bone marrow mapping 

March 10, 2019

New 3D imaging shows how cells, tissues and proteins are distributed within bone marrow. 

International Research Highlight
Improving stem cell donation

February 10, 2019

Stem cells could be collected from donors more safely by using a less invasive catheter.

KAIMRC Research Highlight
A step closer to stem cell therapies for bone disease

February 10, 2019

Controlling a protein’s levels could guide stem cell differentiation for treatment of bone disease.

KAIMRC Research Highlight
Managing salivary gland damage

February 10, 2019

Drugs that stimulate saliva production are the most effective treatment option for managing damage caused by radiotherapy.

International Research Highlight
A viral vector to fall back on

February 10, 2019

A highly efficient method for delivering genetic materials to the spinal cord may help in the treatment of an inherited muscle-wasting disease.

Healthy cells for healthy pregnancies

February 10, 2019

Activating a defence gene may reduce damage to cells involved in preeclampsia.

International Research Highlight
Mining big data highlights importance of ‘junk DNA’

February 10, 2019

An exploratory bioinformatics investigation suggests ‘junk DNA’ plays a critical role in early embryonic development and species evolution.

International Research Highlight
Injury prevention could stem opioid abus

February 10, 2019

People are 1.4 times more likely to become persistent users of opioid painkillers after suffering a traumatic injury.

KAIMRC Research Highlight
Combating MERS in camels with a single-dose vaccine

January 9, 2019

Anti-MERS vaccines for camels could be optimized by varying their viral and DNA content, and adjusting their administration.

International Research Highlight
Running sensors on patient power

October 8, 2017

Sensors that generate electricity from the digestive tract may enable long-term monitoring of patient health.

KAIMRC Research Highlight
How to tell bone marrow cells apart

September 28, 2017

Stem cells in the bone marrow express different molecular markers depending on whether they form bone or other tissue types.Abbr

KAIMRC Research Highlight
Nanocarriers to light up and treat disease

September 6, 2017

Cancer and other diseases could be diagnosed, treated and monitored by multi-tasking biodegradable nanoparticles.

International Research Highlight
Going with the flow in brain mapping

July 9, 2017

Recording changes in cerebral blood flow makes mapping active brain areas possible during visual stimulation.

KAIMRC Research Highlight
DNA circles help predict stem cell therapy outcomes

June 24, 2017

DNA ringlets carried by immune cells could provide routine insight into the progress of stem-cell-based immunotherapy.

International Research Highlight
Beta cell boost could replace insulin injections

February 28, 2017

A strategy for deriving beta cells from patients with type I diabetes could transform disease treatment.

KAIMRC Research Highlight
Smart nanoparticles for cancer drug delivery

January 10, 2017

Magneto-fluorescent nanoparticles successfully deliver anti-cancer drug to breast cancer cells.

KAIMRC Research Highlight
Balancing CT dose and image quality

December 25, 2016

New techniques to improve image quality in CT scans while reducing radiation dose may compromise quality at certain thresholds, potentially resulting in misdiagnosis.

KAIMRC Research Highlight
Light-responsive shape-changing molecules

December 13, 2016

Nanowires that undergo reversible shape-changes in response to light could act as artificial tails to steer drugs around the body.

International Research Highlight
Making room for regeneration

November 1, 2016

Drugs that prevent the accumulation of scar-forming molecules could facilitate nerve repair in multiple sclerosis and other disorders.

KAIMRC Research Highlight
Recipes for better drug delivery

August 14, 2016

Fine-tuned nanocarriers loaded with natural products may improve targeted drug delivery and enhance anti-cancer activity

International Research Highlight
Silkworms’ sweet success

August 14, 2016

Silkworms could point toward a new preventative therapy for type II diabetes.

International Research Highlight
A protective coat for nanoparticles

August 14, 2016

Nanoparticles coated in a ‘don’t-eat-me’ protein can evade the body’s immune system, improving chances of successful drug delivery.

International Research Highlight
Drug-carrying nanoparticles not reaching targets

August 11, 2016

 The targeted delivery of drug-carrying nanoparticles to solid tumours needs improvement before it can be effective in humans.

KAIMRC Research Highlight
Manipulating metals for medicine

August 11, 2016

A simple and robust synthetic method could help magnetic metal oxide nanoparticles reach their potential as a powerful clinical tool.